Graceful Aging
And while you can’t stop aging, you can take steps to delay the aging process and improve some biomarkers related to aging (like cholesterol, glucose, and inflammation). Eating a healthy diet, sleeping well, reducing stress, and participating in both strength and cardiovascular exercise can all promote healthy aging and increase longevity.
But if you’ve already built a solid foundation in those areas of life, you may still wonder if there’s more you can do to ensure your healthy longevity – perhaps you’ve wondered if any supplements that may slow down the aging process…
Being a focus of research for decades, scientists have identified a large number of substances with anti-aging properties, many of which can be taken as supplements by those looking for natural ways to slow down aging process and prevent age-related diseases.
Introducing AEON
Achieve Beautiful Skin & Long-term Health by Optimising Your Metabolism. Don’t settle for a single ingredient to support healthy aging. AEON is the only product to offer an 11-compound longevity complex that addresses everything from oxidative stress, glycation, telomere shortening, to side reactions, and mutations*.
New studies show each of these compounds when taken daily extend life in mice & primates up to 30% *. Promising studies in humans are currently underway.
Furthermore, a synergistic effect happens when they’re compounded that has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death *.
Below we’ll break down the origin, and effects of each ingredient in AEON with links to independent, peer-reviewed studies.
NICOTINAMIDE DUO™
Nicotinamide DUO™ is a proprietary NAD+ precursor developed by Perpetua.Life® Biotech based on a an 80/20 blend of Mono/Riboside (LNR) which has been found to boost NAD+ level even higher than Riboside alone.
NAD+ is a compound found in every cell in your body and involved in many critical processes, including energy metabolism, DNA repair and gene expression. [22, 23]
NAD+ levels decline with age, and this decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s. [23]
Studies have shown that supplementing with NAD+ precursors like NR restores NAD+ levels and prevents age-related physical decline. [24]
For example, a study in aging subjects demonstrated that supplementing orally with Nicotinamide Mono prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity. [24B]
A 2019 study in 12 men with an average age of 75 showed that supplementing with up to 1 gram of Nicotinamide daily for 21 days increased NAD+ levels in skeletal muscle and reduced levels of inflammatory proteins in the body. [25] FISETIN
Fisetin is a plant pigment (flavonoid) compound that’s considered a senotherapeutic, meaning it can kill senescent cells.
Fisetin as an anti-cancer agent targeting the growth signaling pathways. [F01]
Rodent studies suggest that it may reduce the number of senescent cells in tissues and extend lifespan. [41]
Fisetin & its role in chronic diseases. [F02]
Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy. [F03]
Fisetin & Quercetin: Promising flavonoids with chemo-preventive potential. [F03]
Fisetin: A dietary antioxidant for health promotion. [F04]
Exploring the molecular targets of dietary flavonoid Fisetin in cancer. [F05]
ASTRAGALUS
Astragalus membranaceus is a stress-reducing herb used in traditional Chinese medicine. It may help combat aging by reducing oxidative stress, promoting immune function and preventing cellular damage. [40]
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro. [A2]
Astragalus membranaceus: A review of its protection against inflammation and gastrointestinal cancers. [A1]
Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives with astragalus. [A3]
Experimental and clinical studies of mechanisms of the anti-aging effects of chemical compounds in Astragalus membranaceus. [A4]
Astragalus (a traditional Chinese medicine) for treating chronic kidney disease. [A5]
RESVERATROL
Resveratrol is a polyphenol in grapes, berries, peanuts, and red wine that may promote longevity by activating certain genes called sirtuins. It has been shown to increase the lifespan of fruit flies, yeasts, and nematodes. [42]
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a periodontitis model. [R5]
Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. [Q4]
Effects of Resveratrol and other polyphenols on Sirt1: Relevance to brain function during aging. [R4]
Resveratrol, an Nrf2 activator, alleviates aging-related progressive renal injury. [R3]
Role of Resveratrol in regulation of cellular defense systems against oxidative stress. [R2]
Effect of Resveratrol and pterostilbene on aging and longevity. [R1] QUERCETIN
Quercetin is a plant pigment (flavonoid). It is found in many plants and foods, such as red wine.
Quercetin has antioxidant and anti-inflammatory effects which might help reduce inflammation, kill cancer cells, control blood sugar and help prevent heart disease. [Q1]
Quercetin in cancer prevention and therapy. [Q2]
Fisetin & Quercetin: Promising flavonoids with chemo preventive potential. [F03]
Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer. [Q3]
A preliminary investigation demonstrating the effect of Quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray. [Q4]
Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. [Q4B]
EPIGALLOCATECHIN GALLATE
Epigallocatechin Gallate (EGCG) is a well-known polyphenol compound concentrated in green tea. It offers impressive health benefits, with research supporting its use to reduce the risk of certain cancers, as well as other health conditions like heart disease and may prevent or slow fibroid growth. [9, 10, 11, 12]
Among EGCG’s diverse array of potential health-promoting properties is its ability to promote longevity and protect against age-related disease development.
EGCG may slow aging by restoring mitochondrial function in cells and acting on pathways involved in aging, including the AMP-activated protein kinase signalling pathway (AMPK).
It also induces autophagy, the process by which your body removes damaged cellular material. [12]
EGCG intake has been associated with a reduced risk of all-cause mortality, diabetes, stroke and heart-disease-related death. Plus, animal studies have shown that it can protect against skin aging and wrinkles caused by ultraviolet (UV) light. [13, 14, 15] SPERMIDINE
Spermidine has anti-inflammatory & anti-antioxidant properties and can also enhance respiration and metabolic function. Increased dietary spermidine intake is thought to reduce the risk of diseases like cancer, metabolic disease, heart disease and neurodegeneration. [1]
It can also improve memory and slow cognitive decline, as autophagy clears Alzheimer’s-causing amyloid-beta plaques in the brain and can thereby be used to prevent memory loss in older people suffering from mild dementia. [2]
TRIMETHYLGLYCINE
TMG (Trimethylglycine) is produced by our body and is found naturally in beetroot and other foods. It’s also available as a supplement, sometimes used to enhance athletic performance and improve heart & liver health.
TMG is involved in a chemical process called methylation, which is essential for DNA production. [NIH Source]
TMG has outstanding effects on controlling homocysteine levels in the blood. Homocysteine significantly increases around the middle stage of life, and it’s linked to the development of heart disease and stroke.
In a breast cancer study, having more TMG in patients’ diets was linked to fewer deaths from cancer. [NIH Source]
In another study of more than 2800 lung cancer patients, high betaine intake was found to be protective against lung cancer. [NIH Source]
A study including 193 senior citizens showed that an increase in TMG was linked to improvements in response time, memory, and brain function. People whose TMG levels went up the most also saw the most improvement in their memories. [NIH Source]
Additionally, TMG is also being explored as treatment for other neurological disorders such as Alzheimer’s disease. [NIH Source]
L-THEANINE
L-Theanine is an amino acid concentrated in certain teas, including green tea. It may help protect against mental decline and has been shown to extend the lifespan of roundworms by around 5%. [35, 36]
l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. [T1]
Protective effect and mechanism of Theanine on Lipopolysaccharide-induced inflammation and acute liver injury. [T2]
L-Theanine extends lifespan of adult Caenorhabditis elegans. [T3]
The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. [T4]
l-Theanine prevents long-term affective and cognitive side effects of adolescent Δ-9-Tetrahydrocannabinol exposure and blocks associated molecular and neuronal abnormalities in the Mesocorticolimbic Circuitry. [T5]
How to take AEON?
For best absorption, It's advised AEON be taken with a full meal. Recent research has shown great promise with ED administration around noon. A full dose is considered 2 capsules, that can be taken together or split AM / PM.
How to choose the dosage?
Can I take AEON indefinitely?
Yes, our capsules are intended to be taken indefinitely as a dietary supplement. AEON is most effective when used daily over an extended period of time.
Is AEON designed to be consumed by women and men?
AEON is for anyone looking to support their cellular health, and combat the symptoms of aging.
Is 500mg too low/high a serving for Nicotinamide (NMN) DUO ?
500mg is a sufficient daily serving. The serving size of 500mg NMN DUO per day is supported by multiple published human clinical studies. This serving size is clinically shown to increase Nicotinamide Adenine Dinucleotide (NAD+) levels in people and maintain those elevated NAD+ levels with continued daily use.
However, you can safely double your dose to 1,000mg of Nicotinamide (NMN) DUO (4 capsules per day) if you so choose.
What makes AEON worth the cost?
Every ingredient in AEON has been carefully selected to maximize its effectiveness. If you purchased each of AEON compounds separately the cost would be north of $480 per month.
Is AEON third party tested?
AEON is manufactured in the United States, from the highest quality ingredients in partnership with a GMP/NSF certified, FDA registered facility in New York.
Potency, and Heavy Metal testing is conducted on finished product by Twin Arbor Labs in Paso Robles, California; an independent GLP compliant laboratory, accredited to ISO/IEC 17025:2017.
Here at Perpetua.Life we pride ourselves on unrivaled quality standards, and transparency. All of our products are formulated, manufactured, and distributed to the same standards of the pharmaceutical industry.
For the latest lab test results refer to the "Testing" tab in the product description.
Where is AEON manufactured?
AEON is manufactured in the United States, from the highest quality ingredients in partnership with a GMP/NSF certified, FDA registered facility in New York.
